Persistence of parasite antigenemia following diethylcarbamazine therapy of bancroftian filariasis.
Identifieur interne : 00E247 ( Main/Exploration ); précédent : 00E246; suivant : 00E248Persistence of parasite antigenemia following diethylcarbamazine therapy of bancroftian filariasis.
Auteurs : G J Weil [États-Unis] ; K V Sethumadhavan ; S. Santhanam ; D C Jain ; T K GhoshSource :
- The American journal of tropical medicine and hygiene [ 0002-9637 ] ; 1988.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antihelminthe (biosynthèse), Antigènes d'helminthe (sang), Diéthylcarbamazine (usage thérapeutique), Filariose lymphatique (immunologie), Filariose lymphatique (traitement médicamenteux), Filarioses (traitement médicamenteux), Humains, Immunoglobuline G (biosynthèse), Techniques immunoenzymatiques, Wuchereria (immunologie), Wuchereria bancrofti (immunologie), Études de suivi.
- MESH :
- biosynthèse : Anticorps antihelminthe, Immunoglobuline G.
- immunologie : Filariose lymphatique, Wuchereria, Wuchereria bancrofti.
- sang : Antigènes d'helminthe.
- traitement médicamenteux : Filariose lymphatique, Filarioses.
- usage thérapeutique : Diéthylcarbamazine.
- Animaux, Humains, Techniques immunoenzymatiques, Études de suivi.
English descriptors
- KwdEn :
- Animals, Antibodies, Helminth (biosynthesis), Antigens, Helminth (blood), Diethylcarbamazine (therapeutic use), Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (immunology), Filariasis (drug therapy), Follow-Up Studies, Humans, Immunoenzyme Techniques, Immunoglobulin G (biosynthesis), Wuchereria (immunology), Wuchereria bancrofti (immunology).
- MESH :
- chemical , biosynthesis : Antibodies, Helminth, Immunoglobulin G.
- chemical , blood : Antigens, Helminth.
- chemical , therapeutic use : Diethylcarbamazine.
- drug therapy : Elephantiasis, Filarial, Filariasis.
- immunology : Elephantiasis, Filarial, Wuchereria, Wuchereria bancrofti.
- Animals, Follow-Up Studies, Humans, Immunoenzyme Techniques.
Abstract
This study was designed to reexamine the efficacy of diethylcarbamazine for bancroftian filariasis with special reference to changes in serum parasite antigen levels and antifilarial antibody titers after treatment. Patients with asymptomatic microfilaremia were treated with 6 mg/kg diethylcarbamazine daily for 12 days. Microfilaria counts fell dramatically after treatment, as expected. IgG antibody titers to adult and microfilarial antigens of B. malayi were increased 1 month after treatment in most patients. Titers fell slowly to or below pretreatment levels, but remained positive during subsequent months. Parasite antigen levels, measured by monoclonal antibody-based enzyme immunoassay, decreased to 72%, 58%, 53%, and 48% of pretreatment values 1, 3, 6, and 12 months after diethylcarbamazine treatment, respectively. Parasite antigen levels decreased similarly in subjects with and without residual microfilaremia after treatment. These results suggest that diethylcarbamazine has only partial macrofilaricidal activity against W. bancrofti with this dosage schedule. The sustained, impressive reductions in microfilaria counts after treatment despite significant persistence of parasite antigenemia may be explained by sublethal effects of the drug on adult worms. We believe that parasite antigen detection represents a valuable new approach for monitoring the efficacy of antifilarial drug therapy which we hope will lead to improved use of existing drugs and aid in the evaluation of new drugs for filariasis.
PubMed: 3079315
Affiliations:
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Santhanam</name></author><author><name sortKey="Jain, D C" sort="Jain, D C" uniqKey="Jain D" first="D C" last="Jain">D C Jain</name></author><author><name sortKey="Ghosh, T K" sort="Ghosh, T K" uniqKey="Ghosh T" first="T K" last="Ghosh">T K Ghosh</name></author></analytic><series><title level="j">The American journal of tropical medicine and hygiene</title><idno type="ISSN">0002-9637</idno><imprint><date when="1988" type="published">1988</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Helminth (biosynthesis)</term><term>Antigens, Helminth (blood)</term><term>Diethylcarbamazine (therapeutic use)</term><term>Elephantiasis, Filarial (drug therapy)</term><term>Elephantiasis, Filarial (immunology)</term><term>Filariasis (drug therapy)</term><term>Follow-Up Studies</term><term>Humans</term><term>Immunoenzyme Techniques</term><term>Immunoglobulin G (biosynthesis)</term><term>Wuchereria (immunology)</term><term>Wuchereria bancrofti (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antihelminthe (biosynthèse)</term><term>Antigènes d'helminthe (sang)</term><term>Diéthylcarbamazine (usage thérapeutique)</term><term>Filariose lymphatique (immunologie)</term><term>Filariose lymphatique (traitement médicamenteux)</term><term>Filarioses (traitement médicamenteux)</term><term>Humains</term><term>Immunoglobuline G (biosynthèse)</term><term>Techniques immunoenzymatiques</term><term>Wuchereria (immunologie)</term><term>Wuchereria bancrofti (immunologie)</term><term>Études de suivi</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antibodies, Helminth</term><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antigens, Helminth</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Diethylcarbamazine</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Anticorps antihelminthe</term><term>Immunoglobuline G</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Filariasis</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Filariose lymphatique</term><term>Wuchereria</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Wuchereria</term><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Antigènes d'helminthe</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term><term>Filarioses</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Diéthylcarbamazine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Follow-Up Studies</term><term>Humans</term><term>Immunoenzyme Techniques</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Techniques immunoenzymatiques</term><term>Études de suivi</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study was designed to reexamine the efficacy of diethylcarbamazine for bancroftian filariasis with special reference to changes in serum parasite antigen levels and antifilarial antibody titers after treatment. Patients with asymptomatic microfilaremia were treated with 6 mg/kg diethylcarbamazine daily for 12 days. Microfilaria counts fell dramatically after treatment, as expected. IgG antibody titers to adult and microfilarial antigens of B. malayi were increased 1 month after treatment in most patients. Titers fell slowly to or below pretreatment levels, but remained positive during subsequent months. Parasite antigen levels, measured by monoclonal antibody-based enzyme immunoassay, decreased to 72%, 58%, 53%, and 48% of pretreatment values 1, 3, 6, and 12 months after diethylcarbamazine treatment, respectively. Parasite antigen levels decreased similarly in subjects with and without residual microfilaremia after treatment. These results suggest that diethylcarbamazine has only partial macrofilaricidal activity against W. bancrofti with this dosage schedule. The sustained, impressive reductions in microfilaria counts after treatment despite significant persistence of parasite antigenemia may be explained by sublethal effects of the drug on adult worms. We believe that parasite antigen detection represents a valuable new approach for monitoring the efficacy of antifilarial drug therapy which we hope will lead to improved use of existing drugs and aid in the evaluation of new drugs for filariasis.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Missouri (État)</li></region></list><tree><noCountry><name sortKey="Ghosh, T K" sort="Ghosh, T K" uniqKey="Ghosh T" first="T K" last="Ghosh">T K Ghosh</name><name sortKey="Jain, D C" sort="Jain, D C" uniqKey="Jain D" first="D C" last="Jain">D C Jain</name><name sortKey="Santhanam, S" sort="Santhanam, S" uniqKey="Santhanam S" first="S" last="Santhanam">S. Santhanam</name><name sortKey="Sethumadhavan, K V" sort="Sethumadhavan, K V" uniqKey="Sethumadhavan K" first="K V" last="Sethumadhavan">K V Sethumadhavan</name></noCountry><country name="États-Unis"><region name="Missouri (État)"><name sortKey="Weil, G J" sort="Weil, G J" uniqKey="Weil G" first="G J" last="Weil">G J Weil</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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